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Cello

The High-Performance Capillary Electrophoresis Platform Behind REM’s Microbiome Testing

Precision. Throughput. Flexibility. Redefined.

Cello is the technology platform that runs REM’s microbiome assays, combining precision measurement with throughput suitable for clinical workflows, research applications and product validation.

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Proven Performance, Real-World Impact

Cello combines Cycling Temperature Capillary Electrophoresis (CTCE) with automated workflows and validated protocols. This combination provides consistent and high-resolution DNA separation across microbiome, clinical, agricultural and industrial applications.

Performance at a Glance

Automated
96-capillary system

High throughput with minimal manual intervention

Multiplex detection

Dual laser and 6-channel fluorescence for complex assays in single runs

Simplified data analysis

Built-in algorithms automate peak calling and pattern recognition, reducing the expertise required for data interpretation

Customizable
platform

Adaptable consumables and protocols for diverse applications

Why Capillary Electrophoresis?

Capillary electrophoresis separates DNA fragments differing by a single nucleotide, while maintaining throughput. Cello brings single-nucleotide resolution to targeted assays, distinguishing and quantifying closely related organisms across microbiome, clinical and industrial R&D applications.

Strain-Level Resolution

Down to single-nucleotide differences where genetic diversity permits

Rapid Turnaround

From DNA to reported results in hours to days, suitable for routine and study workflows.

Reproducibility

Consistent results across runs, batches and longitudinal studies.

Cost-effectiveness

Scales efficiently for routine testing or high-volume applications

Flexible Platform

Customizable for diverse applications beyond microbiome

Automated Workflow

96-well plate loading and processing with minimal manual intervention

Cello in Today’s Workflows

Quantifies individual Lactobacillus species, Gardnerella vaginalis, and selected Candida species, distinguishing closely related strains. Cello supports CE-marked vaginal assays used in clinical studies and women’s health diagnostics to monitor microbiome composition and guide treatment decisions.

Measures Bifidobacterium communities at the species and subspecies level. Cello’s resolution differentiates closely related organisms with distinct roles in immune development, metabolic programming, and neurological health. Applications range from infant and pediatric gut health monitoring to adult probiotic validation and personalized dietary interventions.

Quantifies Bacillus and other functionally important soil bacteria in agricultural fields and bioinoculant products. Cello provides precise relative abundance measurements for validating product formulations, assessing field efficacy and supporting regenerative agriculture research.

Identifies pathogens and detects antimicrobial resistance (AMR) markers with single-nucleotide precision. Early proof-of-concept work with Cello has demonstrated differentiation of closely related bacterial variants, showing potential for strain typing, outbreak investigation and infection control studies where precise genetic distinctions matter clinically.

Ready to Explore Cello for Your Applications?

We support clients throughout the Cello adoption process, from initial evaluation and method development through validation and routine implementation.

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